HOUSTON -- Seven years to the day after they used six pitchers to throw the first no-hitter against the New York Yankees in nearly a half century, the Astros will return to New York to make their first appearance at new Yankee Stadium on June 11, 2010, to begin a three-game Interleague series.

The Astros' second trip to the Bronx to play the Yankees (June 11-13) is the highlight of the club's 2010 schedule, which was released Tuesday.

Houston once again opens the regular season at home April 5, with a three-game series against the San Francisco Giants. After playing host to the Giants (April 5-7) and Philadelphia Phillies (April 9-11), the Astros will play their first road game April 12 at St. Louis.

In their only previous visit to New York to face the Yankees, the Astros lost two of three games June 10-12, 2003, but became the first team since 1958 to throw a no-hitter against the Yankees when Roy Oswalt, Pete Munro, Kirk Saarloos, Brad Lidge, Octavio Dotel and Billy Wagner combined to accomplish the feat in the middle game of the series.

The Astros will also travel to the Kansas City Royals (June 15-17) and Texas Rangers (June 25-27) in Interleague Play, and will play host to the Tampa Bay Rays (May 21-23) and Rangers (June 18-20) of the American League. The games against the Rangers are the 10th annual installment of Lone Star Series.

The Astros will finish the regular season at home against National League Central division rival Chicago Cubs, Oct. 1-3.