CINCINNATI -- Astros starting pitcher Bud Norris left Tuesday's game against the Reds in the third inning with discomfort in his right shoulder.

Norris, making his second-to-last start of the season, struck out Reds catcher Devin Mesoraco for the second out of the inning, then threw two strikes to Paul Janish, when manager Brad Mills and head athletic trainer Nate Lucero came to the mound. Norris walked off with Lucero and was replaced by Lucas Harrell.

Norris gave up three runs and seven hits, including a two-run homer to Mesoraco, and struck out three batters in 2 2/3 innings.

Coming into the game, Norris was 6-10 with a 3.68 ERA. He has won just once in his last 13 starts despite pitching pretty well in that span. It's unknown whether he'll be able to make his last start of the season Sunday against the Rockies in Houston.