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04/27/12 11:19 PM ET

Lee leaves game with ankle sprain

CINCINNATI -- Astros first baseman Carlos Lee did everything he could to stay in Friday night's game, but his badly sprained left ankle forced him to leave in the first inning.

"I rolled it pretty good," Lee said. "It takes a lot to get me out of a game. I felt like I needed to come out. I'll see how I feel tomorrow."

The injury occurred when Lee planted his foot awkwardly while trying to retrieve a low throw from third baseman Chris Johnson, who had fielded a slow roller from Reds shortstop Zack Cozart leading off the inning. Matt Downs replaced Lee at first base.

Lee's ankle was visibly swollen after Friday night's 6-4 win.

"He'll be out for a couple of days," Astros manager Brad Mills said. "He received treatment the whole game. He sprained it really good." X-rays taken of Lee's ankle were negative.

Lee has been red-hot, going 7-for-7 with a home run and four RBIs in his past four games.

Jeff Wallner is a contributor to MLB.com. This story was not subject to the approval of Major League Baseball or its clubs.